Registration Dossier
Registration Dossier
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EC number: 275-108-6 | CAS number: 71002-20-5
Endpoint summary
Administrative data
Description of key information
No deaths or toxicologicall significant observations at 5000 mg/kg.
In a 14-day dose range finding toxicity study no mortality was observed up to and including 1000 mg/kg/day.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- 5 male and 5 female Wistar rats were dosed with a single oral gavage dose of 5000 mg/kg.
- GLP compliance:
- yes
- Test type:
- other: limit test with 5000 mg/kg
- Limit test:
- yes
- Specific details on test material used for the study:
- Evercion Red H-E 7B Dry Powder.
Seperate statement confirms that the test item is Reactive Red 141; CAS 71002-20-5. - Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- yes
- Statistics:
- not applicable
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- no mortality
- Clinical signs:
- other: no clinical signs
- Gross pathology:
- no observations
- Other findings:
- no effects reported
- Interpretation of results:
- GHS criteria not met
- Executive summary:
No deaths or clinical signes reported.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- No deaths or toxicologicall significant observations at 5000 mg/kg. In a 14-day dose range finding toxicity study no mortality was observed up to and including 1000 mg/kg/day.
Additional information
Justification for classification or non-classification
No deaths or toxicologicall significant observations at 5000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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