Registration Dossier
Registration Dossier
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EC number: 206-556-2 | CAS number: 354-32-5
Endpoint summary
Administrative data
Description of key information
The gas Trifluoroacetyl chloride is extremely unstable in water. In contact with water or aqueous media it will react immediately to produce Trifluoroacetic acid and HCl, which are both considered as corrosive acids. For this reason TFAC is also considered as corrosive for skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
The gas Trifluoroacetyl chloride is extremely unstable in water. In contact with water or aqueous media it will react immediately to produce Trifluoroacetic acid and HCl, which are both considered as corrosive acids. Even a small volume of gas in contact with the eye or skin would be expected to produce concentrations of corrosive acids.
Skin irritation
No studies of dermal irritation / corrosion have been performed with the substance and none are proposed, based on scientific considerations and for reasons of animal welfare. In accordance with column 2 of REACH Annex VII, the in-vitro skin irritation study (required in section 8.1) does not need to be conducted as the available information indicates that the criteria are met for classification as corrosive to the skin.
Eye irritation
No studies on eye irritation have been performed with the substance and none are proposed, based on scientific considerations and for reasons of animal welfare. In accordance with column 2 of REACH Annex VII, the in-vitro eye irritation study (required in section 8.2) does not need to be conducted as the available information indicates that the criteria are met for classification as corrosive to the skin.
Justification for classification or non-classification
No harmonized classification is available for Trifluoroacetyl chloride. In contact with water or aqueous media it will react immediately to produce Trifluoroacetic acid and HCl, which are both considered as corrosive acids. Therefore TFAC is classified according to CLP Regulation (EC) 1272/2008 as corrosive to skin Cat. 1B (H314) and corrosive to eyes Cat. 1 (H318).
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