Registration Dossier
Registration Dossier
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EC number: 206-556-2 | CAS number: 354-32-5
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
As TFAC readily decomposes in water, the study is technically not feasible. Data on the hydrolysis product TFA, which is the actual species present in the environment, is therefore considered to be relevant.
The Log Kow of TFA = 0.79 (+/-0.48) (estimated)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.79
- at the temperature of:
- 25 °C
Additional information
An experimental study is available for TFA but it was disregarded as the substance was dissociated under the test conditions.
The partition coefficient of TFA was therefore estimated using QSAR calculation. Three models, using different methodologies, were run, one was considered as valid, the two others not assignable. As a general rule, QSARs refer to the undissociated form of the molecule (log Kow definition), except for SPARC, which calculates log D as a function of pH; for this model, the value at pH=0 was retained, to allow comparison. A total of 10 consistent results was obtained, within the range 0.21-1.78, which is significantly below the threshold of 4, with regard to classification criteria (long-term aquatic toxicity). The arithmetical mean value of these 10 results (0.79 +/-0.48) will be retained. It should also be noticed that this mean is consistent with the value of the valid KOWWIN QSAR (Log Kow 0.50).
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