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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: clinical case reports
Adequacy of study:
supporting study
Study period:
circa 1982 - 1998
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Case reports of childred accidentally ingesting nitroethane

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Nitroethane poisoning from an artificial fingernail remover.
Author:
Hornfeldt, C.S. and Rabe, W.H.
Year:
1994
Bibliographic source:
Clin Toxicol 32(3): 321-324.
Reference Type:
publication
Title:
Rebound severe methemoglobinemia from ingestion of a nitroethane artificial-fingernail remover
Author:
Osterhoudt, K.C., Wiley, C.C., Dudley, R., Sheen, S. and Henretig, F.M.
Year:
1995
Bibliographic source:
J Pediatrics 126: 819-821.
Reference Type:
publication
Title:
Prolonged formation of methemoglobin following nitroethane ingestion
Author:
Shepherd, G., Grover, J. and Klein-Schwartz, W.
Year:
1998
Bibliographic source:
Clin Toxicol 36: 613-616
Reference Type:
publication
Title:
Severe Methemogolbinemia following Nitroethane Ingestion
Author:
Wells, S.R. and Anderson, D.A.
Year:
1996
Bibliographic source:
Clinical Toxicology, 34:5, 553 - 636 Poster Session A

Materials and methods

Study type:
poisoning incident
Principles of method if other than guideline:
Case reports of accidental poisoning
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
Nitroethane-containing artificial nail removers. At least one case report cited the test material as 100% nitroethane.

Method

Subjects:
5 children who accidentally ingested artificial nail remover.
Route of exposure:
oral
Reason of exposure:
accidental
Exposure assessment:
estimated

Results and discussion

Clinical signs:
In each instance, cyanosis and methemoglobinemia occurred 5-10 hours after exposure.

Any other information on results incl. tables

The clinical signs resolved after treatment with methylene blue. The delayed onset of methemoglobinemia suggests that a metabolite was responsible. Nitrites are acknowledged as formers of methemoglobin.

Applicant's summary and conclusion

Conclusions:
Cyanosis and methemoglobinemia occurred 5-10 hours after exposure, which resolved after treatment with methylene blue. The delayed onset of methemoglobinemia suggests that a metabolite was responsible.
Executive summary:

Five clinical cases were reported of children accidentally ingesting several drops to 90 ml of artificial fingernail removers containing nitroethane.The cases occurred in children aged 1-3, who ingested anywhere from "a few drops" to 90 ml of the products. In each instance, cyanosis and methemoglobinemia occurred 5-10 hours after exposure, which resolved after treatment with methylene blue. The delayed onset of methemoglobinemia suggests that a metabolite was responsible.