Registration Dossier
Registration Dossier
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EC number: 264-202-2 | CAS number: 63451-47-8
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Additional information
Although the reliability of the studies on methyl methacrylate is limited due to deviations to current carcinogenicity test guidelines (e.g., histopathologic examination was performed on a limited number of organs), they revealed no increase of neoplastic lesions after long-term exposure to methyl methacrylate therefore it is considered that methyl methacrylate has no carcinogenic potential.
Available data are limited on zinc compounds. Zinc deficiency or supplementation may influence carcinogenesis, since promoting and inhibiting actions have been reported. However, there is no clear experimental or epidemiological evidence for a direct carcinogenic action of zinc or its compounds.
Justification for selection of carcinogenicity via oral route endpoint:
A weight of evidence approach has been adopted for this endpoint therefore it was not possible to select only one study.
Justification for selection of carcinogenicity via inhalation route endpoint:
A weight of evidence approach has been adopted for this endpoint therefore it was not possible to select only one study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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