Registration Dossier
Registration Dossier
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EC number: 209-388-8 | CAS number: 575-61-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Remarks:
- Type of genotoxicity: other: not applicable
- Type of information:
- (Q)SAR
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study results are disregarded as the substance is out of the the Applicability Domain (AD) of the model.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- publication
- Title:
- Predicted Mutagenicity
- Author:
- U.S. Environmental Protection
- Bibliographic source:
- T.E.S.T. v.4.1
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: General model for estimating the mutagenicity
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Type of assay:
- other: QSAR
Test material
- Reference substance name:
- 3-benzylidenephthalide
- EC Number:
- 209-388-8
- EC Name:
- 3-benzylidenephthalide
- Cas Number:
- 575-61-1
- Molecular formula:
- C15H10O2
- IUPAC Name:
- 3-benzylidene-2-benzofuran-1-one
- Reference substance name:
- 209-388-8.
- IUPAC Name:
- 209-388-8.
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Results and discussion
Test results
- Species / strain:
- other: not applicable
- Metabolic activation:
- not applicable
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Any other information on results incl. tables
Model assessment: Prediction is "mutagenicity = negative", but the result may be not reliable as only moderately similar compounds with known experimental value in the training set have been found.
Details are provided in attachment on the section: "attached full study report".
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The obtained results are disregarded as the substance is out from the applicability domain of the model.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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