Registration Dossier
Registration Dossier
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EC number: 203-472-8 | CAS number: 107-20-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity Profile of Chloroacetaldehyde
- Author:
- W.H. Lawrence, E.O. Dillingham, J.E. Turner, J. Autian
- Year:
- 1 972
- Bibliographic source:
- Journal of Pharmaceutical Sciences, Vol. 61, No. 1, Jan. 1972
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Full details of the method not described in this study.
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Chloroacetaldehyde
- EC Number:
- 203-472-8
- EC Name:
- Chloroacetaldehyde
- Cas Number:
- 107-20-0
- Molecular formula:
- C2H3ClO
- IUPAC Name:
- 2-chloroacetaldehyde
- Test material form:
- other: solution in water
- Details on test material:
- 30 % solution in water, purity not reported.
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Induction
- Concentration / amount:
- 0,002 %
Challenge
- Concentration / amount:
- 0,002 %
- No. of animals per dose:
- 5 animals
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 5 animals were treated with a very dilute solution since higher concentrations were extremely irritating and toxic.
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