Registration Dossier
Registration Dossier
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EC number: 700-172-3 | CAS number: 634-55-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA 40 CFR 792
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- ethyl 2-cyano-3-oxobutanoate
- EC Number:
- 700-172-3
- Cas Number:
- 634-55-9
- Molecular formula:
- C7 H9 NO3
- IUPAC Name:
- ethyl 2-cyano-3-oxobutanoate
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- other: Crl : (HA)BR
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation:
- Weight at study initiation:
- Housing:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):
IN-LIFE DATES: From: To:
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: mineral oil
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.2 mL
- Concentration (if solution):25-50-75 %
VEHICLE
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity: - Duration of treatment / exposure:
- 24 & 48 H
- Number of animals:
- 4 animals
- Details on study design:
- See page 18 of report
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- other: 24 and 48 hours
- Score:
- ca. 0
- Remarks on result:
- other: concentration of 25 and 100 % w/v in mineral oil
- Irritation parameter:
- overall irritation score
- Basis:
- animal #2
- Time point:
- other: 24 and 48 hours
- Score:
- ca. 0
- Remarks on result:
- other: Concentration 50 et 75 % w/v in mineral oil
- Irritation parameter:
- overall irritation score
- Basis:
- animal #3
- Time point:
- other: 24 and 48 hours
- Score:
- ca. 0
- Remarks on result:
- other: Concentration 25 and 75 % w/v in mineral oil
- Irritation parameter:
- overall irritation score
- Basis:
- animal #4
- Time point:
- other: 24 and 48 hours
- Score:
- ca. 0
- Remarks on result:
- other: Concentration of 50 and 100 % w/v in mineral oil
- Irritant / corrosive response data:
- No dermal irritation was observed with any test material concentration (page 15 of report)
- Other effects:
- all animals appeared normal during this phase of the study
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: 40 CFR 792 (EPA - TSCA)
- Conclusions:
- No dermal irritation was observed with any test material concentration
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