Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 939-137-4 | CAS number: -
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Piperazine-Induced Occupational Asthma
- Author:
- Hagmar L., et al
- Year:
- 1 982
- Bibliographic source:
- Journal of Occupational Medicine, Vol. 24, No 3
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- survey
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Survey of workers in a chemical factory.
- GLP compliance:
- no
Test material
- Reference substance name:
- Piperazine
- EC Number:
- 203-808-3
- EC Name:
- Piperazine
- Cas Number:
- 110-85-0
- Molecular formula:
- C4H10N2
- IUPAC Name:
- piperazine
- Details on test material:
- - Name of test material (as cited in study report): piperazine
- Analytical purity: no data
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 130
- Sex: 129 males, 1 female - Route of administration:
- inhalation
Results and discussion
- Results of examinations:
- About one third of the workers in the group with the highest exposures, suffered from symptoms of asthma, and a dose-response relationship was evident for the studied cohort.
Any other information on results incl. tables
Eleven persons presently employed were asthmatic or had experienced asthma associated with exposure to chemicals. In 13 former employees medical reports supported the diagnosis of occupational asthma associated with chemicals. The criteria for diagnosis was recurrent dyspnoea with wheezing breathing and coughing, in association with exposure to agent. The agent was judged to be piperazine in 29 persons and ethylene diamine in 3 persons.
Applicant's summary and conclusion
- Conclusions:
- Piperazine is a respiratory sensitiser in Human.
- Executive summary:
In a survey of workers in a chemical factory inquiries among the employees regarding airway symptoms, smoking habits and chronic bronchitis were conducted. From 130 subject exposed it was judged that 29 persons developed occupational asthma due to exposure of piperazine.
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