Phosphorous trichloride, reaction products with 1,1'-biphenyl and 2,4-bis(1,1-dimethylethyl)phenol

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13 March 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Although not to GLP, this study is conducted using a recognised in-house method by dedicated equipment. The results are fully documented and evaluated.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

no guideline followed

Deviations:

no

Principles of method if other than guideline:

A powder sample of Alkanox P-EPQ (CAS# 119345-01-6, lot# PB002949) was analyzed as received through a #120 (125 μm opening) and a #170 (90 μm opening) sieve. The experiment used a modified version of “Control Test G-32-A Dry Screens”, Uniroyal Chemical Company, Inc., Naugatuck, CT. The sieve screens were visually inspected and found to be free from tears, holes, or other defects. Each sieve and the pan were weighed empty. A 101.79 g sample of P-EPQ was weighed into the top screen of a set of sieves consisting of a top #120 sieve, a middle #170 sieve, and a bottom pan. The top sieve was capped and gently shaken and tapped by hand for 1-2 minutes. The sieves were then placed in a Gilson 8 Inch Sieve Shaker and shaken for 5 minutes. They were removed from the shaker and each sieve and the pan reweighed.

GLP compliance:

no

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

432-130-2

EC Name:

-

Cas Number:

119345-01-6

Molecular formula:

Not applicable ( a generic molecular formula cannot be provided for this UVCB substance)

IUPAC Name:

Reaction products of phosphorous trichloride, with 1,1′-biphenyl and 2,4-bis(1,1-dimethylethyl)phenol

Details on test material:

- Name of test material (as cited in study report): Alkanox P-EPQ
- Molecular formula (if other than submission substance):
C68H92O4P2, CAS# 119345-01-6
C40H51O2P, CAS# 91362-37-7
C42H63O3P, CAS# 31570-04-4
- Molecular weight (if other than submission substance): N/A - UVCB
- Smiles notation (if other than submission substance): N/A - UVCB
- InChl (if other than submission substance): N/A - UVCB
- Structural formula attached as image file (if other than submission substance): See attached report
- Substance type: Organic
- Physical state: Solid
- Analytical purity: 98.5% UVCB
- Impurities (identity and concentrations): 1.5% C14H22O CAS#96-76-4, starting material
- Composition of test material, percentage of components:
65.9% C68H92O4P2, CAS# 119345-01-6
11.2% C40H51O2P, CAS# 91362-37-7
18.6% C42H63O3P, CAS# 31570-04-4
- Isomers composition: N/A
- Purity test date: Not specified
- Lot/batch No.: Lot PB002949
- Expiration date of the lot/batch:N/A
- Radiochemical purity (if radiolabelling):N/A
- Specific activity (if radiolabelling):N/A
- Locations of the label (if radiolabelling):N/A
- Expiration date of radiochemical substance (if radiolabelling):N/A
- Stability under test conditions: Stable
- Storage condition of test material: Not specified
- Other:

Results and discussion

Particle size

Particle size 1

Percentile:

D50

Mean:

>= 90 µm

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Particle size 2

Percentile:

other: 69.7

Mean:

> 125 µm

Particle size 3

Percentile:

other: 13.1

Mean:

> 90 µm

Particle size 4

Percentile:

other: 17.1

Mean:

<= 90 µm

Any other information on results incl. tables

A powder sample of Alkanox P-EPQ (CAS# 119345-01-6, lot# PB002949) was analyzed as received

through a 125 μm and a 90 μm sieve.

69.7% of the sample was retained on the 125 μm screen.

13.1% of the sample was retained on the 90 μm screen.

17.1% of the sample was collected below the 90 μm screen.

The full report is attached below.

Applicant's summary and conclusion

Conclusions:

The majority of the test substance is considered to be above the limits associated with inhalation exposure within the inhalable, thoracic or respirable range. In addition, the vapour pressure of the substance is very low. The substance is not considered to pose a physical hazard to inhalation, based on the data endpoints available.

Executive summary:

The majority of the test substance is considered to be above the limits associated with inhalation exposure within the inhalable, thoracic or respirable range. In addition, the vapour pressure of the substance is very low. The substance is not considered to pose a physical hazard to inhalation, based on the data endpoints available.