Registration Dossier
Registration Dossier
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EC number: 218-792-3 | CAS number: 2235-46-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity study in mice
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity of test chemical in mice.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- N,N-diethylbenzamide
- EC Number:
- 216-912-9
- EC Name:
- N,N-diethylbenzamide
- Cas Number:
- 1696-17-9
- Molecular formula:
- C11H15NO
- IUPAC Name:
- N,N-Diethylbenzamide
- Details on test material:
- - IUPAC Name: N,N-Diethylbenzamide- InChI: 1S/C11H15NO/c1-3-12(4-2)11(13)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3- Smiles: c1(C(N(CC)CC)=O)ccccc1- Molecular formula:C11H15NO- Molecular weight :177.245 g/mol- Substance type:Organic- Physical state:Liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- not specified
- Concentrations:
- 142000 mg/m³
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 142 000 mg/m³ air
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 142000 mg/m³.
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation LC50 value was considered to be 142000 mg/m3, when mice were treated with test chemical by inhalation route.
- Executive summary:
Acute inhalation toxicity study of test chemical was conducted in mice at the dose concentration of 142000 mg/m3. 50% mortality was observed at 142000 mg/m³. Hence, LC50 value was considered to be 142000 mg/m3, when mice were treated with test chemical by inhalation route.
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