Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 218-792-3 | CAS number: 2235-46-3
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 2235-46-3
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database; EPI Suite (DERMWIN) Various versions of EPI Suite dating b
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: modelling database
- Principles of method if other than guideline:
- The amount of dermal absorption in mg per square cm of skin per application
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N-diethyl-3-oxobutyramide
- EC Number:
- 218-792-3
- EC Name:
- N,N-diethyl-3-oxobutyramide
- Cas Number:
- 2235-46-3
- Molecular formula:
- C8H15NO2
- IUPAC Name:
- N,N-diethyl-3-oxobutanamide
- Details on test material:
- EC: 218-792-3 Substance Name: N,N-diethyl-3-oxobutyramide Molecular Formula: C8H15NO2
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
Results and discussion
Percutaneous absorption
- Remarks on result:
- other: 0.01600 mg/cm2/event
Applicant's summary and conclusion
- Conclusions:
- Dermal absorption of N,N-diethyl-3-oxobutyramide is estimated as 0.01600 mg/cm2/event (Moderate).
- Executive summary:
Dermal absorption of N,N-diethyl-3-oxobutyramide is estimated as 0.01600 mg/cm2/event (Moderate).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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