Registration Dossier
Registration Dossier
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EC number: 226-102-7 | CAS number: 5280-66-0 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 15865:4.
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- Acute toxicity upon intraperitoneal injection in mice with 7 day observation period.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Manganese, 4-[(5-chloro-4-methyl-2-sulfophenyl)azo]-3-hydroxy-2-naphthalenecarboxylic acid complex
- EC Number:
- 226-102-7
- EC Name:
- Manganese, 4-[(5-chloro-4-methyl-2-sulfophenyl)azo]-3-hydroxy-2-naphthalenecarboxylic acid complex
- Cas Number:
- 5280-66-0
- Molecular formula:
- C18H11N2O6SClMn
- IUPAC Name:
- 10-carboxy-19-chloro-18-methyl-15,15-dioxo-12λ³,14λ³-dioxa-15λ⁶-thia-1λ⁴,22-diaza-13-manganapentacyclo[11.9.0.0²,¹¹.0³,⁸.0¹⁶,²¹]docosa-1(22),2(11),3,5,7,9,16,18,20-nonaene-13,13-bis(ylium)-12,14-diide
- Test material form:
- solid: nanoform
- Details on test material:
- - Physical state: solid
- Name of test material (as cited in study report): Litholechtscharlach 4300, C.I.Pigmentred 48:4, Monoazofarbstoff.
- Analytical purity: 100%
Test materials used in this dossier are all considered to fall under the definition of nano-materials according to the European Commission Recommendation 2011/696/EU as the synthesis and manufacturing of this pigment always yields particulate material with a fine particle size distribution.
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Litholechtscharlach 4300, C.I.Pigmentred 48:4, Monoazofarbstoff.
- Analytical purity: 100 %
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- aqueous suspension
- Details on exposure:
- The concentration in the suspenstion was not the same for all dose groups. Volume applied was 10 ccm per kg bw
- Doses:
- 3000, 1600, 800 and 200 µg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 3000 mg/kg bw, mortality occured within 1 day after dosing. At 1600 mg/kg bw, it occured within 3 days after dosing.
- Clinical signs:
- Dyspnea, spastic gait, atony; Symptoms occured immediately after dosing. Surviving animals recovered within 6 days.
- Gross pathology:
- Precipitates of the substance were found in the abdomen. The liver was clay coloured at the top dose.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
