Registration Dossier
Registration Dossier
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EC number: 700-641-2 | CAS number: 1261240-30-5
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.12 (Mutagenicity - In Vivo Mammalian Erythrocyte Micronucleus Test)
- Version / remarks:
- EEC Directive 92/69, B.12
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes
- Type of assay:
- other: micronucleus assay, chromosome aberration
Test material
- Reference substance name:
- -
- EC Number:
- 431-770-1
- EC Name:
- -
- Cas Number:
- 216698-07-6
- Molecular formula:
- C32H44O4
- IUPAC Name:
- 2-[2-oxo-5-(2,4,4-trimethylpentan-2-yl)-2,3-dihydro-1-benzofuran-3-yl]-4-(2,4,4-trimethylpentan-2-yl)phenyl acetate
1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Corn oil
- No. of animals per sex per dose:
- Male: 1000 mg/kg; No of animals: 5; Sacrifice time: 24 hours
Male: 1000 mg/kg; No of animals: 5; Sacrifice time: 48 hours
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Oberservations: No toxic signs; no letal effects; no cytotoxicity (PCE/NCE).
Applicant's summary and conclusion
- Conclusions:
- Negative
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