Registration Dossier
Registration Dossier
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EC number: 685-618-4 | CAS number: 35194-30-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
iSafeRat® High-Accuracy-Quantitative Structure-Activity Relationship, KREATIS, 2020 :
72h-ErC50 = 11 mg/L (95% CI: 9.6 - 12 mg/L)
72h-NOECr = 3.7 mg/L (95% CI: 3.2 - 4.4 mg/L)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 11 mg/L
- EC10 or NOEC for freshwater algae:
- 3.7 mg/L
Additional information
Two QSAR predictions are available to assess the toxicity of the registered substance to aquatic algae.
The QSAR predictions (KREATiS, 2020) were considered as reliable and were used as key data. The QSAR models have been validated to be compliant with the OECD recommendations for QSAR modelling (OECD, 2004) and predict the endpoint values which would be expected when testing the substance under experimental conditions in a laboratory following OECD Guideline 201. The growth inhibition of algae was determined using two validated QSAR models for the Mechanism of Action (MechoA) in question (MechoA 1.1, i.e. non-polar narcosis) (Bauer et al., 2018). The QSAR models are based on validated data for a training set of 40 chemicals derived from 72-hour ErC50 and 31 chemicals derived from 72-hour NOECr test on algae, for which the concentrations of the test item had been determined by chemical analyses over the test period. The test item falls within the applicability domain of the models and was therefore reliably predicted for its toxicity (72h-ErC50 and NOECr) to algae. Therefore, these endpoint values can be considered valid for use in risk assessment and classification and labelling.
The 72-h ErC50 and NOECr of the registered substance to algae were respectively predicted at 11 mg/L (95% CI: 9.6 - 12 mg/L) and 3.7 mg/L (95% CI: 3.2 - 4.4 mg/L).
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