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Diss Factsheets
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EC number: 603-520-1 | CAS number: 131807-57-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: SETAC-Europe guidelines (published March 1995)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Substance ID: [14C-POP]DPX-JE874
Lot Number: 3048-237
Radiochemical Purity: 99.2%
Specific Activity: 61.8 µCi/mg
Substance ID: [14C-PA]DPX-JE874
Lot Number: 3048-238
Radiochemical Purity: 98.7%
Specific Activity: 58.5 µCi/mg - Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Aerobic Water/sediment systems
- Duration of test (contact time):
- >= 21 - <= 30 d
- Initial conc.:
- 50 µg/L
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- Key result
- Parameter:
- other: DT50 water ([14C-POP]test substance pH 7.1 system)
- Remarks on result:
- other: 0.07 h
- Key result
- Parameter:
- other: DT50 system ([14C-POP]test substance pH 7.1 system)
- Remarks on result:
- other: 0.8 d
- Key result
- Parameter:
- other: DT50 water ([14C-POP]test substance pH 7.7 system)
- Remarks on result:
- other: 0.43 h
- Key result
- Parameter:
- other: DT50 system ([14C-POP]test substance pH 7.7 system)
- Remarks on result:
- other: 0.68 d
- Key result
- Parameter:
- other: DT50 water ([14C-PA]test substance pH 7.7 system)
- Remarks on result:
- other: 0.48 h
- Key result
- Parameter:
- other: DT50 system ([14C-PA]test substance pH 7.7 system)
- Remarks on result:
- other: 2.05 d
- Conclusions:
- Based on this study, the test substance and its degradation products should dissipate rapidly from natural water/sediment systems.
The DT50 values in water and system were 0.007 hours and 0.80 days for the [14C-POP]test substance pH 7.1 system. The DT50 values in water and system were 0.43 hours and 0.68 days or the [14C-POP]test substance pH 7.7 system. The DT50 values in water and system were 0.48 hours and 2.05 days for the [14C-PA]test substance pH 7.7 system. - Executive summary:
The objectives in this study were to determine the rate and pattern of degradation of the test substance in two water/sediment systems and to determine mass balance. The rate of degradation of the test substance was evaluated using the [14C-POP]test substance in two water/sediment systems with differing characteristics: pH 7.1 and pH 7.7 systems (pH of the aqueous phase). The route of degradation of [14C-PA]test substance was characterized in the pH 7.7 system so that the degradation and metabolism of the parent molecule could be fully assessed. This study demonstrated that the test substance is readily and completely degraded under aerobic conditions in a water/sediment system.
The DT50 values in water and system were 0.007 hours and 0.80 days for the [14C-POP]test substance pH 7.1 system. The DT50 values in water and system were 0.43 hours and 0.68 days for the [14CPOP]test substance pH 7.7 system. The DT50 values in water and system were 0.48 hours and 2.05 days for the [14C-PA]test substance pH 7.7 system.
The DT90 values in water and system were 23 hours and 15 days for the [14C-POP]test substance pH 7.1 system. The DT90 values in water and system were 1.6 hours and 14 days for the [14C-POP]test substance pH 7.7 system. The DT90 values in water and system were 1.7 hours and 54 days for the [14C-PA]test substance pH 7.7 system.
The DT50 and DT90 values were generally in good agreement between all systems, even though the [14C-PA]test substance system was designed to assess the route of degradation only (smaller number of sample intervals). The difference between the DT90 value in the PA and POP labels may be caused by the smaller number or time points which may have skewed the data. The mean mass balance in all systems was over 92%.
In both [14C-POP]test substance systems, the major terminal degradation products of the test substance were CO2 and unextractable residues. The patterns of formation and decline of IN-KZ007, IN-H3310, IN-JL856, and IN-JS940 were well established in all systems by 21 to 30 days. As the test substance and its metabolites declined in the water/sediment systems, CO2 and unextractable residues increased.
In the [14C-PA]test substance system, the major terminal degradation product of the test substance was unextractable residues. The patterns of formation and decline of IN-KZ007, IN-JL856 and the polar degradation products were well established by 21 days. The formation of organic volatile component(s) reached a plateau at 14 days of <10% of the applied radioactivity. As the test substance and its metabolites declined in the water/sediment systems, the unextractable residues increased.
Based on this study, the test substance and its degradation products should dissipate rapidly from natural water/sediment systems.
Reference
Description of key information
Study Type | Study Details | Value | Guideline | Reliability |
Biodegradation in water | Biodegradation in Aerobic Water/sediment systems | Readily Biodegradable | SETAC-Europe guidelines | 1 |
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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