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Diss Factsheets

Physical & Chemical properties

Melting point / freezing point

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes
Type of method:
capillary method
Specific details on test material used for the study:
Substance name: Famoxadone (DPX-JE874)
Lot #: JE874-313
Purity: 99.4%
Key result
Melting / freezing pt.:
141.3 - 142.3 °C

A summary of the temperatures at the different stages of melting are presented in the following table:














































Replicate



Wet Point (°C)



Shrinkable Point (°C)



Collapse Point (°C)



Liquifying Point (°C)



Final stage of melting (°C)



1



-



141.5



142.5



142.5



142.5



2



-



141.5



142



142.5



142.5



3



141



141-142



142



142



142



Mean



 



141.3



142.2



142.3



142.3


Conclusions:
Melting point: 141.3 -142.3°C (414.4 - 415.4 K)
Executive summary:

The study was conducted according to OECD guideline 102, EEC method A.1, and OPPTS 830.7200.


Based on the preliminary test, the stages of melting for test substance were observed at 141, 141, 142, 143 and 143°C (wet point, shrinkage point, collapse point, liquefying point and final stage of melting, respectively).


The average melting range for the test substance was determined to be 141.3-142.3°C (414.4 - 415.4 K) (K = °C + 273.15). The test substance melted to a clear, colorless liquid.

Description of key information

OECD 102; EU Method A.1; OPPTS 830.7200

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
141.3 °C

Additional information