Registration Dossier
Registration Dossier
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EC number: 641-487-5 | CAS number: 40150-92-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Relevant details on materials and methods + results not provided
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-ol
- Cas Number:
- 40150-92-3
- Molecular formula:
- C12 H18 O
- IUPAC Name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-ol
- Details on test material:
- No further data provided
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- - Treated for 24 hours with liquid test material under an oooluslve wrapping.
- wrapping was removed after the 24 hour exposure period.
- skin wiped free of excess test material with an absorbent pad and warm water. - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: at frequent intervals for the first 6h; twice daily for mortality, clinical signs, skin conditions
- Necropsy of survivors performed: yes
- Clinical signs including body weight: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/10 animals
- Clinical signs:
- other: skin irritation: slight to moderate erythema and edema (over most of 14 days) -> essentially resolved at study end No other clinical signs observed
- Gross pathology:
- no test substance related effects observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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