Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-533-5 | CAS number: 584-13-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4H-1,2,4-triazol-4-ylamine
- EC Number:
- 209-533-5
- EC Name:
- 4H-1,2,4-triazol-4-ylamine
- Cas Number:
- 584-13-4
- Molecular formula:
- C2H4N4
- IUPAC Name:
- 4H-1,2,4-triazol-4-ylamine
- Test material form:
- solid
- Details on test material:
- supplier: Aldrich company
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 h
- Observation period:
- 1, 24, 48, 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 6x6 cm
- Type of wrap if used: semi-occlusive patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
SCORING SYSTEM: according to the grading system given in OECD Test Guideline 404 (Acute toxicity: Dermal Irritation/Corrosion), Council Regulation (EC) No.440/2008
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Primary Irritation Index = (SUM Erythema 24/48/72hr + SUM Oedema 24/48/72hr) / 3× No. of animals = 0
Applicant's summary and conclusion
- Interpretation of results:
- other: Criteria used for interpretation of results: EU
- Conclusions:
- The test substance, 4H-1,2,4-triazol-4-ylamine, was tested for acute dermal irritation/corrosion.
Six rabbits were exposed to 0.5 g of test substance, applied onto clipped skin for 4 hours using a semi-occlusive dressing. Skin reactions were evaluated after patch removal and observations were made at the 1, 24, 48 and 72 hours after exposure.
No skin irritation was caused by 4-hour exposure to tested substance. - Executive summary:
The test substance, 4H-1,2,4-triazol-4-ylamine, was tested in the study for acute dermal irritation/corrosion.
Test was performed according to acc. OECD Test Guideline 404 (Acute Toxicity: Dermal Irritation/Corrosion).
Six rabbits were exposed to 0.5 g of test substance, applied onto clipped skin for 4 hours using a semi-occlusive dressing. Skin reactions were evaluated after patch removal and observations were made at the 1, 24, 48 and 72 hours after exposure. No skin irritation was caused by 4-hour exposure to tested substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
