Registration Dossier
Registration Dossier
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EC number: 615-738-4 | CAS number: 72245-35-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrolysis product of chloro(dimethyl)octadecylsilane and silica gel
- EC Number:
- 615-738-4
- Cas Number:
- 72245-35-3
- Molecular formula:
- SiC20H43
- IUPAC Name:
- Hydrolysis product of chloro(dimethyl)octadecylsilane and silica gel
1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- no systemic signs of toxicity.
- Body weight:
- All animals showed weight gain at the end of the study.
- Gross pathology:
- No macroscopic changes were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 is > 2000 mg/kg.
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