Registration Dossier
Registration Dossier
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EC number: 225-472-7 | CAS number: 4866-00-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06.12.2000 - 08.01.2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test performed according to GLP and OECD guidelines, choice of positive controls is different to guidline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 4-methyloxazole-5-carboxamide
- EC Number:
- 225-472-7
- EC Name:
- 4-methyloxazole-5-carboxamide
- Cas Number:
- 4866-00-6
- Molecular formula:
- C5H6N2O2
- IUPAC Name:
- 4-methyl-1,3-oxazole-5-carboxamide
Constituent 1
Method
- Target gene:
- TA97, TA98, TA100, TA102 and TA 1535
Species / strain
- Species / strain / cell type:
- bacteria, other: TA 1535, TA 97,TA 98, TA 100 und TA 102
- Additional strain / cell type characteristics:
- DNA polymerase A deficient
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- 5 mg / plate
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- benzo(a)pyrene
- Remarks:
- Migrated to IUCLID6: 4-Nitro-1,2-phenylendiamin, Sodium azide
Results and discussion
Test results
- Species / strain:
- bacteria, other: TA 1535, TA 97,TA 98, TA 100 und TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
no other information
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Substance is not mutagenic - Executive summary:
-
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