Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-472-7 | CAS number: 4866-00-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03.11. - 18.11.2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: test performed according to OECD and GLP guidelines, purity not stated in the report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 4-methyloxazole-5-carboxamide
- EC Number:
- 225-472-7
- EC Name:
- 4-methyloxazole-5-carboxamide
- Cas Number:
- 4866-00-6
- Molecular formula:
- C5H6N2O2
- IUPAC Name:
- 4-methyl-1,3-oxazole-5-carboxamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 per sex
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
no other information
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of Oxazolamid in the acute oral toxicity study in rats of both sexes was estimated to be greater than 2000 mg/kg.
- Executive summary:
The test substance was administered orally in two fractions of total of 2000 mg per kg weight to one group of 5 male and 5 female Sprague-Dawley rats. Under the conditions of this experiment Oxazolamid caused no mortality. No acute toxicological symptoms attributed to the exposure to Oxazolamid could be observed in 10 out of 10 rats on the day of administration and on the 15 days after administration. The post-mortem findings after euthanasia did not show any macroscopic organ changes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
