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EC number: 814-602-3 | CAS number: 190454-06-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 March 2018 to 14 September 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- < 2 µg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- >= 6.9 - <= 7.7
- Details on results:
- Preliminary Test
- The content of test material dissolved in the water sample was 0.308 mg/L.
Main Study
- Small responses at the retention time of the test material were detected in the chromatograms of the samples. The measured concentrations were extrapolated since they were all below the calibration curve hence the water solubility of the test material is given as lower than the lowest calibration solution while taking a dilution factor of 2 into account (i.e. < 2.00 μg/L). - Conclusions:
- Under the conditions of this study, the water solubility of the test material at 20 °C was < 2.00 μg/L.
- Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105, EU Method A.6 and OPPTS 830.7840, under GLP conditions.
The slow-stirring flask method was applied for the determination of the water solubility of the test material. The pH of the aqueous samples was 6.9 to 7.7.
Under the conditions of this study, the water solubility of the test material at 20 °C was < 2.00 μg/L.
Reference
Table 1: Main Study - Water Solubility of the Test Material at Low Nominal Level
Stirring Time [hours] |
Analysed Concentration [μg/L] |
Mean [μg/L] |
pH |
24 |
< 2.00 |
< 2.00 |
6.9 |
48 |
< 2.00 |
7.1 |
|
72 |
< 2.00 |
7.1 |
Table 2: Main Study - Water Solubility of the Test Material at High Nominal Level
Stirring Time [hours] |
Analysed Concentration [μg/L] |
Mean [μg/L] |
pH |
24 |
< 2.00 |
< 2.00 |
7.3 |
48 |
< 2.00 |
7.5 |
|
72 |
< 2.00 |
7.7 |
Description of key information
Under the conditions of the study, the water solubility of the test material at 20 °C was < 2.00 μg/L.
Key value for chemical safety assessment
Additional information
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105, EU Method A.6 and OPPTS 830.7840, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The slow-stirring flask method was applied for the determination of the water solubility of the test material. The pH of the aqueous samples was 6.9 to 7.7.
Under the conditions of the study, the water solubility of the test material at 20 °C was < 2.00 μg/L.
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