Fatty Acids, C16-18 and C18-unsatd., diesters with 2-(3-hydroxypropyl)-6-[(3-hydroxypropyl)amino]-1H-benz[de]isoquinoline-1,3(2H)-dione)

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04 April 2018 to 24 April 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

2016

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Key result

Atm. press.:

101 325 Pa

Decomposition:

yes

Decomp. temp.:

> 200 °C

Remarks on result:

not determinable

Remarks:

No melting point was determined. Glass transitions of the test material were observed at -48.1 °C (225.0 K), -5.7 °C (267.5 K) and 32.6 °C (305.7 K).

Preliminary Test

- Starting at 300 °C, the weight of the sample decreased significantly. At 410 °C, the sample weight had decreased by 25 %.

- After the experiment, a dark brown residue remained in the sample container (original colour: amber). The change of the colour indicated reaction and/or decomposition of the test material.

 

Main Study

- During cooling, an exothermic peak followed by a glass transition were observed between -80 °C and -50 °C. The exothermic effect was obtained due to crystallisation of the test material. During heating, three glass transitions were observed between -75 °C and 50 °C. The inflection point of the glass transitions were -47.689 °C (first glass transition), -5.573 °C (second glass transition) and 32.361 °C (third glass transition). An endothermic peak directly followed by an exothermic effect was observed starting at 200 °C. The effects were due to reaction and/or decomposition of the test material. After the experiment, an orange/brown residue remained in the sample container.

- Experiment 2 was performed to determine the duplicate glass transitions. The inflection point of the glass transitions were -48.543 °C (first glass transition), -5.807 °C (second glass transition) and 32.830 °C (third glass transition). After the experiment, the sample appeared to have been unchanged, i.e. no decomposition and/or evaporation were observed.

- The glass transition temperature was determined as the mean glass transition temperature of Experiment 1 (-47.689 °C (first glass transition), -5.573 °C (second glass transition) and 32.361 °C (third glass transition)) and Experiment 2 (-48.543 °C (first glass transition), -5.807 °C (second glass transition) and 32.830 °C (third glass transition)).

Conclusions:

Under the conditions of this study, no melting point of the test material was determined. Glass transitions of the test material were observed at -48.1 °C (225.0 K), -5.7 °C (267.5 K) and 32.6 °C (305.7 K). Reaction and/or decomposition of the test material was observed during DSC experiments at temperatures of > 200 °C (> 473 K).

Executive summary:

 The melting point of the test material was investigated in accordance with the standardised guidelines OECD 102, EU Method A.1 and OPPTS 830.7200, under GLP conditions.

The melting temperature of the test material was determined using differential scanning calorimetry (DSC).

Under the conditions of this study, no melting point of the test material was determined. Glass transitions of the test material were observed at -48.1 °C (225.0 K), -5.7 °C (267.5 K) and 32.6 °C (305.7 K). Reaction and/or decomposition of the test material was observed during DSC experiments at temperatures of > 200 °C (> 473 K).

Description of key information

Under the conditions of this study, no melting point of the test material was determined. Glass transitions of the test material were observed at -48.1 °C (225.0 K), -5.7 °C (267.5 K) and 32.6 °C (305.7 K). Reaction and/or decomposition of the test material was observed during DSC experiments at temperatures of > 200 °C (> 473 K).

Additional information

 The melting point of the test material was investigated in accordance with the standardised guidelines OECD 102, EU Method A.1 and OPPTS 830.7200, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The melting temperature of the test material was determined using differential scanning calorimetry (DSC).

Under the conditions of this study, no melting point of the test material was determined. Glass transitions of the test material were observed at -48.1 °C (225.0 K), -5.7 °C (267.5 K) and 32.6 °C (305.7 K). Reaction and/or decomposition of the test material was observed during DSC experiments at temperatures of > 200 °C (> 473 K).