Registration Dossier
Registration Dossier
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EC number: 222-848-2 | CAS number: 3632-91-5
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- march 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM norm E793 06
- Version / remarks:
- Standard Test Method for Enthalpies of Fusion and Crystallization by Differential Scanning Calorimetry
- GLP compliance:
- not specified
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 1500000655
- Expiration date of the lot/batch: 13.03.2018
- Manufacturing date: 14.03.2015 - Melting / freezing pt.:
- >= 169.67 - <= 171.93 °C
- Atm. press.:
- 1 Bar
- Decomposition:
- yes
- Remarks:
- The test item can undergo the decomposition and structural changes during heating and the product of decomposition can have influence on temperature of melting obtained by DSC method.
- Decomp. temp.:
- >= 170.1 - <= 172.1 °C
- Conclusions:
- The determination of melting point of test item is carried out in accordance with the OECD 102 guideline.
The average melting temperature of the test item is determinated to be 170.8 ± 1.13 °C.
Reference
Thermal behaviour of magnesium gluconate is described in publication[1]. This compound exhibited 88.51% weight loss with three stages of thermal degradation process up to 895.18 °C from room temperature. The TGA/DTG thermograms indicated that magnesium gluconate was thermally stable up to around 165°C. Consequently, the melting temperature of magnesium gluconate was found to be 169.90°C along with the enthalpy of fusion of 308.7 J/g.
For determination of melting point, 3 measurements were performed . The decomposition process with mass loss is undergoing during heating. The mass loss estimated before melting of substance is between 4 to 5 % and after melting, mass loss is between 10 up to 13 %.
[1]Mahendra Kumar Trivedi, Neena Dixit, Parthasarathi Panda, Kalyan Kumar Sethi,Snehasis Jana: In-depth investigation on physicochemical and thermal properties of magnesium (II) gluconate using spectroscopic and thermoanalytical techniques Journal of Pharmaceutical Analysis 7 (2017) 332–337
Description of key information
The determination of melting point of test item is carried out in accordance with the OECD 102 guideline.
The average melting temperature of the test item is determinated to be 170.8 ± 1.13 °C.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 170.8 °C
Additional information
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