Registration Dossier
Registration Dossier
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EC number: 262-987-6 | CAS number: 61788-56-5
Endpoint summary
Administrative data
Description of key information
Lithium naphthenate consists of lithium salts of naphthenic acids and is expected to dissociate in the human body to lithium cations and naphthenic acid anions. Therefore, data are presented to address the lithium cations and naphthenic acid anions separately. No human data are available for naphthenic acids. Significant published evidence is available from human exposure to lithium cations. Data on the human serum lithium ion concentration are provided in the Repeated Dose Toxicity Endpoint section.
Additional information
The lithium cation has been used extensively in human therapy for bipolar disease for example, in the form of lithium salts (e.g. carbonate, acetate, sulphate). As a result, considerable information is available on safe serum lithium ion concentrations over long periods of administration. To determine the hazard associated with the lithium ion from lithium naphthenate, it is appropriate to use the human serum lithium ion concentration, converted to equivalent lithium naphthenate concentration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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