Registration Dossier
Registration Dossier
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EC number: 434-600-2 | CAS number: 2628-16-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 434-600-2
- EC Name:
- -
- Cas Number:
- 2628-16-2
- Molecular formula:
- CH3CO2C6H4CH=CH2
- IUPAC Name:
- 4-ethenylphenyl acetate
- Test material form:
- liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- Liver homogenate derived from Aroclor 1254 induced rats (S-9 mix)
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 50...5000 µg/plate
Concentration range in the main test (without metabolic activation): 50...5000 µg/plate - Vehicle / solvent:
- Solvent: Dimethyl sulphoxide
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (5000µg/plate)
- Key result
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (5000 µg/plate)
- Key result
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (5000 µg/plate)
- Additional information on results:
- Observations:
No increases in revertants were obtained with any of the four bacterial strains at the test substance levels tested, either with or without metabolic activation.
Positive controls produced marked increases in the revertant counts. - Remarks on result:
- other:
- Remarks:
- result from preliminary test
Applicant's summary and conclusion
- Conclusions:
- negative with metabolic activation
negative without metabolic activation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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