4-ethenylphenyl acetate

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

not specified in report

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

434-600-2

EC Name:

-

Cas Number:

2628-16-2

Molecular formula:

CH3CO2C6H4CH=CH2

IUPAC Name:

4-ethenylphenyl acetate

Test material form:

liquid

Test solutions

Vehicle:

yes

Remarks:

acetone

Test organisms

Test organisms (species):

Daphnia magna

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

2.85 mg/L

Effect concentrations 2

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

1.66 mg/L

Effect concentrations 3

Key result

Duration:

48 h

Dose descriptor:

EC100

Effect conc.:

5 mg/L

Effect concentrations 4

Key result

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

0.313 mg/L

Details on results:

% concentration loss over test: 100

Any other information on results incl. tables

Analysis of duplicate samples at the beginning and end of the test indicated that intended exposure concentrations of the test substance were achieved but not maintained (at all concentrations, maesured values after 48 hours were below the limit of detection).

At the lowest exposure concentration, 15% of the Daphia were mobile but swimming at the surface of the test medium. No sush floaters were observed at 0.313 mg/ml, but some animals in all exposure groups at higher concentrations were mobile and submerged.

The 48-hour median effect concentration (EC50) for immobilisation, based on nominal concentrations, was calculated to be 1.66 mg/ml (95% confidence limits of 1.35 and 2.11 mg/ml) based on the numbers of floating and/or immobile Daphnia, the 48-hour EC50 was found to be 1.39 mg/ml (95% confidence limits of 1.13 and 1.74 mg/ml)

The test material was found to be susceptible to hydrolysis, so intended exposure limits of the parent material could not be maintained during the test. However, the conditions employed are considered to reflect potential real-life exposure of Daphnia in surface waters following accidental release of the test substance.

Water hardness ranged from 218 to 232 mg CaCO3/1