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EC number: 246-045-1 | CAS number: 24157-81-1
Endpoint summary
Administrative data
Description of key information
For 2,6-DIPN the lipid normalized BCF values were determined as 810 (low dose group; 0.47 µg/L) and 2200 (high dose group; 4.85 µg/L), respectively.
Additional information
No bioaccumulation study concerning only 2,6-diisopropylnaphthalene (CAS 24157-81-1; 2,6-DIPN) was available. But a GLP study according to OECD 305 examining the bioaccumulative potential of Bis(isopropyl)naphthalene (DIPN), an isomeric mixture which consist of seven isomers (1,3-, 1,4-, 1,5-, 1,6-, 2,6- and 2,7-DIPN) is available and used in a read-across approach. In this study the BCF values of the seven isomers was determined individually for each isomer. The determined BCF values differed strongly between the isomers.
According to the recent OECD 305 (2012) as well as the ECHA Guidance Document R.11 (v2.0, 2014), the BCF values should be expressed based on a 5% lipid content. In the original study report the BCF data were not lipid-normalised. Therefore, in an expert statement by ECT Oekotoxikologie GmbH (ETC, 2017) a lipid-normalisation was performed using the data (BCF and lipid content) available in the original study report.
For 2,6-DIPN the lipid normalized BCF values were determined as 810 (low dose group; 0.47 µg/L) and 2200 (high dose group; 4.85 µg/L), respectively. Hence, 2,6-DIPN fulfils the criterion of being bioaccumulative (BCF > 2000) but not very bioaccumulative (BCF < 5000).
Although the environmental relevance of the results from the high exposure concentration is questionable (see expert statement ETC, 2017) the highest measured BCF value of 2200 was used as an worst case assumption for the bioaccumulation assessment. Therefore, 2,6-diisopropylnaphthalene (CAS24157-81-1) was assessed as bioaccumulative (B) but not very bioaccumulative (vB) under environmental conditions.
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