Registration Dossier
Registration Dossier
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EC number: 224-736-9 | CAS number: 4468-02-4
Endpoint summary
Administrative data
Description of key information
A double blind trial (prospective study) was conducted on pregnant women to determine the effects zinc supplementation during pregnancy on maternal and fetal outcome.
494 women booking before 20 weeks of gestation in a hospital were prescribed either 66 mg zinc sulphate (equivalent to 20 mg elemental zinc) capsules or placebo for once daily use, starting from day of booking till delivery. Various adverse outcomes were tested, including maternal bleeding, hypertension, complications of labour and delivery, gestational age, Apgar scores, and neonatal abnormalities. The main outcome measure was birth weight.
There were no differences between the mothers and neonates of the zinc supplemented and placebo group. Under the test conditions, zinc supplementation during pregnancy did not affect maternal or fetal outcome.
This study (Mahomed et al.) is juged relevant to be used in a read-across purpose.
Additional information
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