Methyl 4-[2-[4-(5-methyl-2-benzoxazolyl)phenyl]vinyl]benzoate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March from 11 to 18, 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Reason / purpose for cross-reference:

reference to other study

Remarks:

validated analytical method

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

adopted July 27, 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

19 March 2014

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Version / remarks:

March 1998

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Water solubility:

< 0.001 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

7.5 - 8.3

Details on results:

At 25 ml/h: samples were taken after 67, 68.5, 70, 71.5 and 72 hours. The measured concentrations were under the LOQ (in this case, the LOQ was 0.0005 µg/ml), standard deviation were 11 %.
At 12.5 ml/h: samples were taken after 88 and 92 hours. The measured concentrations were under the LOQ (in this case, the LOQ was 0.0001 µg/ml) and the study was interrupted, because the measured concentrations were under the LOQ after three days.

pH MEASUREMENT
Before the pH measurement, 2-point calibration of the pH meter was performed. The calibrated range was between 7.000 and 10.000, the measurement was performed at 20 ±1 °C. The measured pH values were between 7.5 and 8.3.

Conclusions:

Water solubility < 0.0005 mg/l at 20 °C and pH 7.5 -8.3

Executive summary:

The water solubility of the test item was determined in accordante with the method and procedures outlined into the OECD guideline 105, column elution method. The method is based on the elution of the test substance with water from a micro-column, which is charged with an inert support material coated with an excess of test substance. The water solubility is determined when the mass concentration of the eluate is constant; this is shown by a concentration plateau as a function of time.

At 25 ml/h samples were taken after 67, 68.5, 70, 71.5 and 72 hours and the measured concentrations were under the LOQ (i.e. 0.0005 µg/ml), standard deviation were 11 %. At 12.5 ml/h samples were taken after 88 and 92 hours and the measured concentrations were under the LOQ (i.e. 0.0001 µg/ml) and the study was interrupted, because the measured concentrations were under the LOQ after three days. The test was run at 20 ± 0.5 °C and the measured pH values were between 7.5 and 8.3.

Conclusion

Water solubility < 0.0005 mg/l at 20 °C and pH 7.5 -8.3

Description of key information

Water solubility < 0.0005 mg/l at 20 °C and pH 7.5 -8.3

Additional information

OECD 105 - column elution method