Registration Dossier
Registration Dossier
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EC number: 212-477-4 | CAS number: 821-41-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07.12.1988 to 02.01.1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Hex-5-en-1-ol
- EC Number:
- 212-477-4
- EC Name:
- Hex-5-en-1-ol
- Cas Number:
- 821-41-0
- Molecular formula:
- C6H12O
- IUPAC Name:
- hex-5-en-1-ol
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Rabbits, Small White Russian, Chbb-SPF
Test system
- Type of coverage:
- semiocclusive
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 3 days
- Number of animals:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Already one hour after application necrosis was obseverved, but not after 3 min. Because of the fast corrosive action of the test substance, the study was terminated after treatment of one animal.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Following application of the test substance to the skin of rabbits, severe signs of irritation and necrosis formation can be observed already one hour after application. Therefore, it needs to be concluded that the test substance is corrosive to the skin and is classified as Category 1B according to Regulation (EC) 1272/2008.
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