Registration Dossier
Registration Dossier
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EC number: 212-477-4 | CAS number: 821-41-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28.11.2002 to 05.03.2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Hex-5-en-1-ol
- EC Number:
- 212-477-4
- EC Name:
- Hex-5-en-1-ol
- Cas Number:
- 821-41-0
- Molecular formula:
- C6H12O
- IUPAC Name:
- hex-5-en-1-ol
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality occurred.
- Clinical signs:
- Clinical signs included a moribund appearance, hunched posture, reduced activity and piloerection. Recovery had occurred by Day 2 or 3.
- Body weight:
- Body weight observed in treated animals was slightly reduced.
- Gross pathology:
- No abnonnalities were observed in any animal at necropsy examination.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute toxicity of 5-Hexen-1-ol has been investigated following administration of a single oral dose to the rat. No mortality occurred at 2000 mg/kg. Some clinical signs (moribund appearance, hunched posture, reduced activity and piloerection) were observed during the first 2 or days following dosing and a reduced body weight gain was seen during the 14 day observation period. The results of this study indicate that LD50 after single oral administration of the test item is above the limit dose of 2000 mg/kg.
Since animals were in moribund appearance for the first 2 or 3 days after administration, a classification in Category 5 based on GHS criteria seems warranted.
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