Registration Dossier
Registration Dossier
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EC number: 269-284-3 | CAS number: 68214-04-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 December 2017 to 07 December 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 344.3 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 391.5 g/L
- Incubation duration:
- 74.5 h
- Temp.:
- 20 °C
- pH:
- >= 8.35 - <= 8.93
- Details on results:
- Pre-test:
0.1 g of the test item was weighed into a 10 mL centrifuge vial. In a stepwise procedure, increasing volumes of water were added, namely 0.1 mL, 0.5 mL, 1.0 mL, 2 mL and 10 mL (final volumes). After each addition of an amount of water, the mixture was shaken for 10 min and was visually checked for any undissolved parts of the sample.
Added Volume [mL] 0.1 0.5
Approximate Solubility [g/L] > 1000 1000-200
Dissolution no yes
In the main test all filtrated test solutions showed no Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid). - Conclusions:
- The water solubility of the substance is 344.3 ± 3.3 g/L.
- Executive summary:
In a flask test the water solubility of the substance was assessed to be 344.3 ± 3.3 g/L at 20 °C.
Reference
Equilibration phase
Time |
Tempera |
pH* |
Dilution |
Peak |
Concentration |
Difference to |
24.5 |
20.2 |
n.d. |
8000 |
7.6454 |
353.5 |
- |
7.6437 |
||||||
48 |
20.0 |
n.d. |
8000 |
7.5494 |
348.9 |
-1.3 |
7.5432 |
||||||
72 |
20.2 |
n.d. |
8000 |
7.5705 |
349.9 |
+0.3 |
7.5648 |
*n.d.: Not detectable. pH paper could not be evaluated because the colour was too intense
Measurements at the plateau
Flask |
Temperature |
pH* |
Dilution |
Peak area |
Measured values |
Blank |
19.8 |
6.95 |
- |
n.c. |
- |
n.c. |
|||||
2 |
20.0 |
8.35 |
8000 |
7.3533 |
340.5 |
7.3725 |
|||||
3 |
20.0 |
8.35 |
8000 |
7.5336 |
348.2 |
7.5267 |
|||||
4 |
20.0 |
8.71 |
8000 |
7.3895 |
341.8 |
7.3953 |
|||||
5 |
19.9 |
8.43 |
8000 |
7.5010 |
346.9 |
7.5022 |
|||||
6 |
20.0 |
8.93 |
8000 |
7.4375 |
343.9 |
7.4369 |
* pH at the plateau was tested using a calibrated pH meter
Description of key information
In a flask test the water solubility of the substance was assessed to be 344.3 ± 3.3 g/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 344 g/L
- at the temperature of:
- 20 °C
Additional information
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