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EC number: 611-799-6 | CAS number: 59121-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-06-14 to 1999-11-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,4,6,10-Dodecatetraen-3-ol,3,7,11-trimethyl-,(4E,6E)-
- EC Number:
- 611-799-6
- Cas Number:
- 59121-99-2
- Molecular formula:
- C15H24O
- IUPAC Name:
- 1,4,6,10-Dodecatetraen-3-ol,3,7,11-trimethyl-,(4E,6E)-
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Boehringer Ingelheim Pharma KG
- Age at study initiation: Young adult animals
- Weight at study initiation: 2.72 - 2.97 kg
- Housing: single housing in stainless steel wire mesh cages with grating, floor area : 3000 cm2. No bedding in the cages; wood shavings in the waste trays.
- Diet: Kliba-Labordiet, Klingentalmuehle AG, Kaiseraugst, Switzerland, (about 130 g per animal per day).
- Water: About 250 mL tap water per animal per day.
- Acclimation period: Acclimatization for at least 1 week.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Air changes (per hr): fully air-conditioned rooms
- Photoperiod: 12 h/12 h (6.00 a.m.- 6.00 p.m./6.00 p.m.- 6.00 a.m.)
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin sites of the same animal
- Amount / concentration applied:
- The test patch (2.5 cm x 2.5 cm) was moistened with 0 .5 mL of the unchanged liquid test substance.
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 d
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: Upper third of the back or flanks.
- Type of wrap: Idealbinde, Pfaelzische Verbandstoff-Fabrik, Kaiserslautern and Fixomull(R) stretch (adhesive fleece), Beiersdorf AG
REMOVAL OF TEST SUBSTANCE
- Washing: The test substance was removed at the end of the exposure period with Lutrol(R) = (Polyethylenglycol) and Lutrol(R)/water (1 :1).
- Time after start of exposure: 4 h
SCORING SYSTEM: according to OECD 404 (1992) and EEC directive 92/69 L383A B.4
- Body weight determination: Shortly before application of the test substance.
- Readings: 1 h, 24 h, 48 h, 72 h, 7 d and 14 d after removal of the patch.
- Mortality: A check for any dead or moribund animal was made twice each workday and once on saturdays, sundays and on public holidays.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Irritant / corrosive response data:
- Erythema and edema extending beyond the area of exposure were observed for all three animals from 24 h onward. All three animals showed eczematoid skin change extending beyond the area of exposure after 7 days. Edema were fully reversible for two of three animals, whereas erythema were not fully reversible within 14 days of observation.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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