Registration Dossier
Registration Dossier
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EC number: 272-037-2 | CAS number: 68649-89-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Rosin and Rosin Salts Category - Supporting Documents for Initial Risk-Based Prioritization
- Author:
- U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxics (OPPT) Risk Assessment Division (RAD)
- Year:
- 2 008
- Bibliographic source:
- Rosin and Rosin Salts Category - Supporting Documents for Initial Risk-Based Prioritization, 2008
- Reference Type:
- secondary source
- Title:
- IUCLID dataset for the CAS: 65997-06-0
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID dataset for the CAS: 65997-06-0; EUROPEAN COMMISSION – European Chemicals Bureau; 2000
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study in Rat for CAS no: 65997-06-0
- Author:
- RTECS
- Year:
- 2 017
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance data base ), 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute oral toxicity study of Rosin hydrogenated was performed in Rat
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Rosin, hydrogenated
- EC Number:
- 266-041-3
- EC Name:
- Rosin, hydrogenated
- Cas Number:
- 65997-06-0
- IUPAC Name:
- Rosin hydrogenated
- Details on test material:
- - Name of test material (as cited in study report):Rosin hydrogenated
- Molecular formula :Unspecified
- Molecular weight :Unspecified
- Substance type:organic
- Physical state:No data available
-Purity:No data available
- Impurities (identity and concentrations):No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Rosin hydrogenated
- Molecular formula :Unspecified
- Molecular weight :Unspecified
- Substance type:organic
- Physical state:No data available
-Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 31500 mg/kg bw
- No. of animals per sex per dose:
- Total:20
Male:10
Female:10 - Control animals:
- not specified
- Details on study design:
- Details on study design
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: No data available
- Other examinations performed: No data available - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 31 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be >31500mg/kg body weight. When wistar rats were treated with Rosin hydrogenated (65997-06-0) orally.
- Executive summary:
Acute oral toxicity study was done in wistar rat usingRosin hydrogenated (65997-06-0).10 male and 10 female rats were administered with test material in dose concentration 31500mg/kg bw and observed for14 days .No mortality was observed .HenceLD50 was considered to be >31500mg/kgbody weight. When wistar rats were treated withRosin hydrogenated (65997-06-0) orally.
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