Registration Dossier
Registration Dossier
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EC number: 226-420-6 | CAS number: 5397-31-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 951
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method as described in "The Place of the Range Finding Test in the Industrial Toxicology Laboratory" - H.F. Smyth Jr. and C.P. Carpenter; J. Indust. Hyg. & Toxicol. 26: 269, 1944
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-(2-ethylhexyloxy)propylamine
- EC Number:
- 226-420-6
- EC Name:
- 3-(2-ethylhexyloxy)propylamine
- Cas Number:
- 5397-31-9
- Molecular formula:
- C11H25NO
- IUPAC Name:
- 3-[(2-ethylhexyl)oxy]propan-1-amine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk
- Type of wrap if used: flexible film of rubber, vinyl plastic - Duration of exposure:
- 24 hours
- Doses:
- up to 20 mL/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 304.2 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: corresponds to 0.36 mL/kg bw (conversion in mg/kg bw is based on density of test substance (0.845 g/mL))
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
