Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-401-0 | CAS number: 106-47-8
Classification & Labelling & PBT assessment
GHS
General Information
- Name:
- 4-Chloroaniline
- Implementation:
- EU
Related composition
- Related composition:
- 4-Chloroaniline
Classificationopen allclose all
Explosives
- Reason for no classification:
- data lacking
Flammable gases and chemically unstable gases
- Reason for no classification:
- data lacking
Aerosols
- Reason for no classification:
- data lacking
Oxidising gases
- Reason for no classification:
- data lacking
Gases under pressure
- Reason for no classification:
- data lacking
Flammable liquids
- Reason for no classification:
- data lacking
Flammable solids
- Reason for no classification:
- data lacking
Self-reactive substances and mixtures
- Reason for no classification:
- data lacking
Pyrophoric liquids
- Reason for no classification:
- data lacking
Pyrophoric solids
- Reason for no classification:
- data lacking
Self-heating substances and mixtures
- Reason for no classification:
- data lacking
Substances and mixtures which in contact with water emit flammable gases
- Reason for no classification:
- data lacking
Oxidising liquids
- Reason for no classification:
- data lacking
Oxidising solids
- Reason for no classification:
- data lacking
Organic peroxides
- Reason for no classification:
- data lacking
Corrosive to metals
- Reason for no classification:
- data lacking
Desensitized explosives
- Reason for no classification:
- data lacking
Acute toxicity - oral
- Hazard category:
- Acute Tox. 3
- Hazard statement:
- H301: Toxic if swallowed.
Acute toxicity - dermal
- Hazard category:
- Acute Tox. 3
- Hazard statement:
- H311: Toxic in contact with skin.
Acute toxicity - inhalation
- Hazard category:
- Acute Tox. 3
- Hazard statement:
- H331: Toxic if inhaled.
Skin corrosion / irritation
- Reason for no classification:
- data lacking
Serious eye damage / eye irritation
- Hazard category:
- Eye Irrit. 2B
- Hazard statement:
- H320: Causes eye irritation.
Respiratory sensitisation
- Reason for no classification:
- data lacking
Skin sensitisation
- Hazard category:
- Skin Sens. 1
- Hazard statement:
- H317: May cause an allergic skin reaction.
Aspiration hazard
- Reason for no classification:
- data lacking
Reproductive toxicity
- Reason for no classification:
- data lacking
Effects on or via lactation
- Reason for no classification:
- data lacking
Germ cell mutagenicity
- Hazard category:
- Muta. 2
- Hazard statement:
- H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Carcinogenicity
- Hazard category:
- Carc. 1B
- Hazard statement:
- H350: May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
1. Specific target organ toxicity - single (STOT-SE)
- Hazard category:
- STOT Single Exp. 1
- Hazard statement:
- H370: Causes damage to organs <or state all organs affected, if known> <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Affected organs:
- other: Based on the human evidence including "methemoglobinemia, cyanosis, lethargy, somnolency, headache, dizziness" (CERI Hazard Data 2000-30 (2001)
1. Specific target organ toxicity - repeated (STOT-RE)
- Hazard category:
- STOT Rep. Exp. 1
- Hazard statement:
- H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Affected organs:
- other: Based on the human evidence including "cyanosis, an increase in methemoglobin/sulfhemoglobin levels" (CICAD 48 (2003)) and the evidence from animal studies including "cyanosis, formation of Heinz bodies, a significant decrease in hemoglobin and red blood
1.
- Concentration range (%):
- > 99.5
- Hazard categories:
- Acute Tox. 3
- Carc. 1B
- Expl. Div. 1.1
- Eye Irrit. 2B
- Muta. 2
- Skin Sens. 1
Hazardous to the aquatic environment (acute / short-term)
- Hazard category:
- Aquatic Acute 1
- Hazard statement:
- H400: Very toxic to aquatic life.
Hazardous to the aquatic environment (long-term)
- Hazard category:
- Aquatic Chronic 1
- Hazard statement:
- H410: Very toxic to aquatic life with long lasting effects.
Hazardous to the ozone layer
- Reason for no classification:
- data lacking
- Additional hazard classes:
- Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Labelling
- Signal word:
- Danger
Hazard pictogram
- GHS06: skull and crossbones
- GHS08: health hazard
- GHS09: environment
Hazard statements
- H350: May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- H331: Toxic if inhaled.
- H311: Toxic in contact with skin.
- H301: Toxic if swallowed.
- H317: May cause an allergic skin reaction.
- H410: Very toxic to aquatic life with long lasting effects.
Precautionary statements
- P264: Wash ... thoroughly after handling.
- Precautionary_Statement_Prevention:Acute Toxicity-Oral
- P270: Do not eat, drink or smoke when using this product.
- Precautionary_Statement_Prevention:Acute Toxicity-Oral
- P301+P310: IF SWALLOWED: Immediately call a POISON CENTER/doctor/…
- Acute Toxicity-Oral:Precautionary_Statement_Response:
- P321: Specific treatment (see ... on this label).
- Acute Toxicity-Oral:Precautionary_Statement_Response:
- P330: Rinse mouth.
- Acute Toxicity-Oral:Precautionary_Statement_Response:
- P405: Store locked up.
- Acute Toxicity-Oral:Precautionary_Statement_Storage
- P501: Dispose of contents/container to ...
- Acute Toxicity-Oral:Precautionary_Statement_Disposal
- P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
- Precautionary_Statement_Prevention:Acute Toxicity-Dermal:
- P302+P352: IF ON SKIN: Wash with plenty of water/…
- Precautionary_Statement_Response Acute Toxicity-Dermal:
- P312: Call a POISON CENTER/doctor/.../if you feel unwell.
- Precautionary_Statement_Response Acute Toxicity-Dermal:
- P322: Specific measures (see ... on this label).
- Precautionary_Statement_Response Acute Toxicity-Dermal:
- P361: Take off immediately all contaminated clothing.
- Precautionary_Statement_Response Acute Toxicity-Dermal:
- P363: Wash contaminated clothing before reuse.
- Precautionary_Statement_Response Acute Toxicity-Dermal:
- P405: Store locked up.
- Precautionary_Statement_Storage Acute Toxicity-Dermal:
- P501: Dispose of contents/container to ...
- Precautionary_Statement_Disposal Acute Toxicity-Dermal:
- P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
- Precautionary_Statement_PreventionAcute Toxicity-Inhalation
- P271: Use only outdoors or in a well-ventilated area.
- Precautionary_Statement_Prevention Acute Toxicity-Inhalation
- P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- Precautionary_Statement_Response:Acute Toxicity-Inhalation
- P312: Call a POISON CENTER/doctor/.../if you feel unwell.
- Precautionary_Statement_Response:Acute Toxicity-Inhalation
- P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
- Precautionary_Statement_Prevention: Respiratory or Skin Sensitization:
- P272: Contaminated work clothing should not be allowed out of the workplace.
- Precautionary_Statement_Prevention: Respiratory or Skin Sensitization:
- P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
- Precautionary_Statement_Prevention: Respiratory or Skin Sensitization:
- P302+P352: IF ON SKIN: Wash with plenty of water/…
- Precautionary_Statement_Response: Respiratory or Skin Sensitization:
- P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
- Precautionary_Statement_Response: Respiratory or Skin Sensitization:
- P321: Specific treatment (see ... on this label).
- Precautionary_Statement_Response: Respiratory or Skin Sensitization
- P363: Wash contaminated clothing before reuse.
- Precautionary_Statement_Response: Respiratory or Skin Sensitization
- P501: Dispose of contents/container to ...
- Precautionary_Statement_Disposal: Respiratory or Skin Sensitization
- P201: Obtain special instructions before use.
- Precautionary_Statement_Prevention: Germ Cell Mutagenicity
- P202: Do not handle until all safety precautions have been read and understood.
- Precautionary_Statement_Prevention: Germ Cell Mutagenicity
- P281: Use personal protective equipment as required.
- Precautionary_Statement_Prevention: Germ Cell Mutagenicity
- P308+P313: IF exposed or concerned: Get medical advice/attention.
- Precautionary_Statement_Response: Germ Cell Mutagenicity
- P405: Store locked up.
- Precautionary_Statement_Storage: Germ Cell Mutagenicity
- P501: Dispose of contents/container to ...
- Precautionary_Statement_Disposal: Germ Cell Mutagenicity
- P201: Obtain special instructions before use.
- Precautionary_Statement_Prevention:Carcinogenicity
- P202: Do not handle until all safety precautions have been read and understood.
- Precautionary_Statement_Prevention:Carcinogenicity
- P381: In case of leakage eliminate all ignition sources.
- Precautionary_Statement_Prevention:Carcinogenicity
- P308+P313: IF exposed or concerned: Get medical advice/attention.
- Precautionary_Statement_Response:Carcinogenicity
- P405: Store locked up.
- Precautionary_Statement_Storage:Carcinogenicity
- P501: Dispose of contents/container to ...
- Precautionary_Statement_disposalCarcinogenicity
- P273: Avoid release to the environment.
- Precautionary_Statement_Prevention: Hazards to the Aquatic Environment:
- P391: Collect spillage.
- Precautionary_Statement_Response: Hazards to the Aquatic Environment:
- P501: Dispose of contents/container to ...
- Precautionary_Statement_Disposal: Hazards to the Aquatic Environment:
Additional labelling requirements
- EUH006: Explosive with or without contact with air.
Notes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
