Registration Dossier
Registration Dossier
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EC number: 202-947-7 | CAS number: 101-50-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: Standard Draize Test
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from authorative handbook and reliable database
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- DPIM: AJS500
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials), (Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.: , 1972, 192. )
Materials and methods
- Principles of method if other than guideline:
- Data is from SAX and RTECS
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-aminoazobenzene-3,4'-disulphonic acid
- EC Number:
- 202-947-7
- EC Name:
- 4-aminoazobenzene-3,4'-disulphonic acid
- Cas Number:
- 101-50-8
- Molecular formula:
- C12H11N3O6S2
- IUPAC Name:
- 4-aminoazobenzene-3,4'-disulphonic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material: 4-aminoazobenzene-3, 4’-disulphonic acid- Molecular formula: C12H11N3O6S2- Molecular weight: 357.36 g/mol- Substance type: Organic
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24H
- Observation period (in vivo):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24h
- Reversibility:
- not specified
- Remarks on result:
- other: Mild irritation
- Irritant / corrosive response data:
- No data available
- Other effects:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Mildly irritant
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The 4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8) was found to be mildly irritating to eye of rabbit.
- Executive summary:
4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8) was administered to eye of rabbit at 500 mg of concentration for 24 hrs. Mild irritation was observed after 24 hrs.
Therefore, the 4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8) was found to be mildly irritating to eye of rabbit.
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