Registration Dossier
Registration Dossier
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EC number: 609-124-5 | CAS number: 3541-81-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- -
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Phosphonium, (3-methyl-4-oxo-2-butenyl)triphenyl-, chloride
- EC Number:
- 609-124-5
- Cas Number:
- 3541-81-9
- Molecular formula:
- C23 H22 O P . Cl
- IUPAC Name:
- Phosphonium, (3-methyl-4-oxo-2-butenyl)triphenyl-, chloride
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- not rinsed
- Observation period (in vivo):
- 21 d
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 7 d
- Score:
- 2.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 21 d
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 5.33
- Max. score:
- 6
- Reversibility:
- fully reversible within: 21 d
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
