Registration Dossier
Registration Dossier
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EC number: 609-124-5 | CAS number: 3541-81-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented guideline study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- -
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Phosphonium, (3-methyl-4-oxo-2-butenyl)triphenyl-, chloride
- EC Number:
- 609-124-5
- Cas Number:
- 3541-81-9
- Molecular formula:
- C23 H22 O P . Cl
- IUPAC Name:
- Phosphonium, (3-methyl-4-oxo-2-butenyl)triphenyl-, chloride
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 h
- Other effects:
- -
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- substance is not irritating
- Executive summary:
In this study Wittigaldehydechloride was applied as such for 4 hours semi-occlusive to assess its primary skin irritation potential
on rabbits.
Experimental data reported indicate that the test article can be classified as not irritating for the rabbit skin.
No corrosive effect occurred on the treated skin of any animal at each measuring interval.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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