Registration Dossier
Registration Dossier
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EC number: 231-639-5 | CAS number: 7664-93-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII
- Author:
- Smyth HF jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA & Nycum JS
- Year:
- 1 969
- Bibliographic source:
- Am Ind Hyg Assoc J. 1969 Sep-Oct; 30(5):470-6
- Reference Type:
- secondary source
- Title:
- SULFURIC ACID CAS No. 7664-93-9: SIDS Initial Assessment Report for 11th SIAM
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The study was performed as part of a series of 'range-finding' tests performed with a large number of industrial chemicals. The protocol for acute oral toxicity is broadly similar to OECD 401 in that groups of rats were gavaged with a single dose of the test material and observed for 14 days.
- GLP compliance:
- no
- Remarks:
- : the study pre-dates GLP.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sulphuric acid
- EC Number:
- 231-639-5
- EC Name:
- Sulphuric acid
- Cas Number:
- 7664-93-9
- Molecular formula:
- H2O4S
- IUPAC Name:
- sulfuric acid
- Details on test material:
- The test material is described as reagent grade sulphuric acid, whic implies 95-98% sulphuric acid.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- A logarithmic series of doses were used, but are not reported. Sulphuric acid was administered in water at 0.25 g/ml.
- No. of animals per sex per dose:
- Five animals of a single sex were used
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 140 mg/kg bw
- 95% CL:
- >= 1 540 - <= 2 990
Any other information on results incl. tables
Only limited details of the results for individual chemicals are reported in this study, which reports basic toxicity screening data for a large nunber of chemicals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The results of this study indicate that sulphuric acid is of low acute oral toxicity when gastric intubation is used as the method of administration. Sulphuric acid is not classified for acute oral toxicity according to current EU criteria.
- Executive summary:
Unfasted Carworth-Wistar rats (5 of a single sex per dose group) were gavaged with sulphuric acid and observed for 14 days. Based on the pattern of mortalities, the 'most probable median lethal dose' is reported to be 2140 (1540 -2990) mg/kg bw.
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