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EC number: 249-854-8 | CAS number: 29797-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The geometric mean of LC0 and LC100 for dichloromethylbenzene mixture to Danio rerio was determined to be 2.2 mg/L for 96h. The LC0 was 1.8 mg/L and the LC100 was 2.6 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.2 mg/L
Additional information
Key study
In a 96-h acute toxicity study, Danio rerio were exposed to the dichloromethylbenzene mixture at nominal concentrations of 2.8 - 44 mg/L under semi-static conditions. Analytical monitoring was performed. The authors determined the 96-h LC0 to be 2.2 mg/L and the LC100 to be 4.3 mg/L. The LC0 and LC50 values were recalculated during dossier preparation as geometric mean values based on the measured concentrations, resulting in an LC0 of 1.8 mg/L and an LC100 of 2.6 mg/L. The geometric mean of these endpoints was determined to be 2.2 mg/L.
The study was performed according to GLP and followed a method which is comparable with the required guideline and is therefore considered to fulfil the requirements for a key study.
Reference: Caspers & Müller, 1992
Supporting studies
In a 96-h acute toxicity study, Oryzias latipes were exposed to 2,4-dichlorotoluene at nominal concentrations of 1.0 - 10 mg/L under semi-static conditions. The OECD-Guideline 203 was followed. Analytical monitoring was not performed.
A 96-h LC50 of 2.7 mg/L was determined based on nominal concentrations. A vehicle was used and controls with and without vehicle were run.
Reference: EA Japan, 1992
In a 96-h acute toxicity study, Pimephales promelas were exposed to 3,4-dichlorotoluene. It was a flow-through system and the tested concentrations were between 0.85 and 6.59 mg/L (nominal) and between 0.7 and 5.35 mg/L (mean measured).
A 96-h LC50 of 2.91 mg/L was determined based on mean measured concentrations.
Reference: Brooker, 1984
In a 96-h acute toxicity study, Danio rerio were exposed to 2,3-dichlorotoluene. It was a static system. Due to a very steep dose-response-curve, an LC50 could not be estimated. A 96-h LC0 of 42.2 mg/L and an LC100 of 56.2 mg/L were determined based on nominal concentrations.
The geometric mean of these values was calculated to be 48.7 mg/L.
Reference: Bernhofen-Klinke, 1985
In a 96-h acute toxicity study, Oryzias latipes were exposed to 2,6-dichlorotoluene.
A 96-h LC50 of 6.4 mg/L was determined.
Reference: Ueda, 1993
In a 96-h acute toxicity study, Danio rerio were exposed to an isomeric mixture with a higher amount of 2,6-dichlorotoluene. It was a flow-through test system and analytical monitoring was performed.
A 96-h LC50 of 3.24 mg/L was determined.
Reference: FhG, 1989
Further study
In a 96-h acute toxicity study, Danio rerio were exposed to 2,4-dichlorotoluene. Further details are not available.
A 96-h LC0 of > 100 mg/L was determined based on nominal concentrations.
Since only a short abstract is available and the determined endpoint is not relevant, the study is considered not to be reliable.
Reference: Bayer, <= 1995
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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