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EC number: 639-566-4 | CAS number: 165184-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1994; 1961
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Hexylcinnamaldehyde is an alkyl-substituted cinnamaldehyde and therefore structurally similar enough to justify read-across. Cinnamic acid is the initial metabolite of cinnamaldehyde. Further justification included as attachement within endpoint summary. One of the studies is very old and probably less reliable. Nevertheless they are included here as supporting data to the metabolism of cinnamaldehyde provided as weight of evidence in this endpoint.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 961
Materials and methods
Test material
Constituent 1
Test animals
- Species:
- other: rat; mouse; human
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Cinnamic acid is readily excreted in rat, mouse and human. The main urinary metabolite is hippuric acid. - Executive summary:
The effect of dose on the disposition of [3-14C]-cinnamic acid in F344 rats and CD1 mice has been studied [Nutley et al., 1994]. Five dose levels of cinnamic acid in the range from 0.0005 mmol/kg bw (0.072 mg/kg bw) to 2.5 mmol/kg bw (370 mg/kg bw) were given orally to groups of F344 rats (4/group) or by intraperitoneal injection to groups of CD1 mice (4/group). After 24 hours, 73-88% of the radioactivity was recovered in the urine of rats and 78-93% in the urine of mice. After 72 hours, 84¬97% of the radioactivity was recovered from rats mainly in the urine. In mice, the recovery was 89-100% within 72 hours. Only trace amounts of radioactivity were present in the carcasses, indicating that cinnamic acid was readily and quantitatively excreted at all dose levels. In both species the main urinary metabolite was hippuric acid although in the mouse, the excretion of cinnamoylglycine was significant at lower doses.
Eleven adult volunteers received single intravenous doses of cinnamic acid, equivalent to 5 mg/kg bw (Quarto di Palo et al, 1961). Analysis of the blood plasma revealed cinnamic acid at 100% of the total dose within 2.5 minutes declining to 0% after 20 minutes. Ninety minutes after dosing, urinalysis revealed mainly the glycine conjugate of benzoic acid (hippuric acid), cinnamoylglucuronide, and benzoylglucuronide present in a ratio of 74:24.5:1.5 (Quarto di Palo and Bertolini, 1961). These data demonstrate that cinnamic acid is rapidly oxidized to benzoic acid metabolites, and excreted in the urine of humans.
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