Registration Dossier
Registration Dossier
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EC number: 202-613-0 | CAS number: 97-86-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Embryonic-Fetal Toxicity and Teratogenic Effects of a Group of Methacrylate Esters in Rats
- Author:
- Singh AR, Lawrence WH, Autian J
- Year:
- 1 972
- Bibliographic source:
- Journal of Dental Research. 51: 1632-1638
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isobutyl methacrylate
- EC Number:
- 202-613-0
- EC Name:
- Isobutyl methacrylate
- Cas Number:
- 97-86-9
- Molecular formula:
- C8H14O2
- IUPAC Name:
- isobutyl methacrylate
- Details on test material:
- Rohm & Haas Philadeliphia, Pa., no more data available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- The test animals were 175 to 225 gm, adult, virgin female rats. Male rats of thesame strain and age were
used as the "stud pool".
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on study design:
- Acute toxicity was determined by administration of graded doses of these specific samples by intraperitoneal
injection in rats and observation of the rats for 7 days for mortality. - Statistics:
- Acute LD50-values and 95 % confidence limits were calculated by Cornfield and Mantel's modification of Karber's
method or by the method of Weil.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 981 - 1 568 mg/kg bw
- Remarks on result:
- other: Original value: 1.3999 ml/kg (1.1077 - 1.7693 ml/kg 95 % confidence limit) Density: 0.886 g/cm3
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
