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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Screening test; data presented in sufficient detail, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Development of a toxicity evaluation program for dental materials and products; II. Screening for systemic toxicity.
Author:
Lawrence WH, Malik M, Autian J
Year:
1974
Bibliographic source:
J Biomed Mater Res 8: 11-34

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: not known
Principles of method if other than guideline:
LT50
GLP compliance:
not specified
Test type:
other: LT50

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutyl methacrylate
EC Number:
202-613-0
EC Name:
Isobutyl methacrylate
Cas Number:
97-86-9
Molecular formula:
C8H14O2
IUPAC Name:
isobutyl methacrylate
Specific details on test material used for the study:
Purity: no data available but typically >= 99%

Test animals

Species:
mouse
Strain:
ICR
Sex:
male
Details on test animals or test system and environmental conditions:
Male ICR mice

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
The chamber consists of 8.75 l, all glass container, into which air, containing vapors of the test material, is passed at a rate of 2 l/min. Filtered, compressed air is directed into a flask containing the test sample. The air may be either bubbled through the liquid or the stream of air may be directed down onto the surface of the test sample.
Under these conditions, the time required for th echamber atmosphere to reach 80% equilibrium with the incoming air-vapor mixture is 7.04 min and 99% equilibrium in about 20 min.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
290 min
Concentrations:
The test concentrations were calculated by weighing the flask with the  test material prior to and after the test.
No. of animals per sex per dose:
5 males
Control animals:
not specified
Details on study design:
5 male ICR mice were exposed in an inhalation chamber (8.75 l).Air flow 2 l/min. The air 
(filtered compressed air) was bubbled  through the liquid test material.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: LT50
Effect level:
29.74 mg/L air
Exp. duration:
290 min
Remarks on result:
other: 29.74 mg/l =5056 ppm

Applicant's summary and conclusion

Conclusions:
A reliable published study indicates the LT50 of the test substance in mice is 290 minutes at 29.74 mg/L.
Executive summary:

A reliable published study indicates the LT50 of the test substance in mice is 290 minutes at 29.74 mg/L.