Registration Dossier
Registration Dossier
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EC number: 202-859-9 | CAS number: 100-51-6
Long-term toxicity to fish
Administrative data
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- (Q)SAR calculated endpoint
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
The substance is readily biodegradable and considered to be of low risk to fish.
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- EPI Suite v 4.0/ECOSAR v1.00
- Author:
- US EPA
- Year:
- 2 014
- Bibliographic source:
- http://epa.gov/oppt/exposure/pubs/episuite.htm
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
Test material
- Reference substance name:
- Benzyl alcohol
- EC Number:
- 202-859-9
- EC Name:
- Benzyl alcohol
- Cas Number:
- 100-51-6
- Molecular formula:
- C7H8O
- IUPAC Name:
- phenylmethanol
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not required
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- other: Fish species
- Details on test organisms:
- no further information
Study design
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 d
Test conditions
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : OCc(cccc1)c1
CHEM : Benzenemethanol
CAS Num: 100-51-6
MOL FOR: C7 H8 O1
MOL WT : 108.14
Log Kow: 1.08 (KowWin estimate)
Wat Sol: 4.29E+004 mg/L (experimental database) - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 48.897 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic , as determined by (Q)SAR
- Details on results:
- A NOEC value of 48.897 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
Any other information on results incl. tables
Overview of QSARs estimations onlong-term aquatic toxicity of benzyl alcohol to fish
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Fish, 96-hr LC50 =504.664 mg/L (ppm) Fish 30-day ChV = 48.897 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Fish, 96-hr LC50 =504.664mg/L (ppm)
Fish 30-day ChV =48.897mg/L (ppm)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- A NOEC value of 48.897 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
- Executive summary:
The ECOSAR QSAR model predicts that the NOEC for freshwater fish would to be 48.897 mg/l .This result signifies that the test substance is not expected to be toxic .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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