Registration Dossier
Registration Dossier
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EC number: 234-454-8 | CAS number: 12004-35-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No data for long-term toxicity to fish are available for the test substance Nickel aluminate. However, there are reliable data available for different structurally analogue test substances.
The environmental fate pathways and ecotoxicity effects assessments for Ni metal and Ni compounds is based on the observation that adverse effects to aquatic, soil- and sediment-dwelling organisms are a consequence of exposure to the bioavailable Ni-ion, released by the parent compound. The result of this assumption is that the ecotoxicology will be similar for all soluble Ni substances used in the ecotoxicity experiments. Therefore, data from soluble nickel substances are used in the derivation of ecotoxicological and environmental fate endpoints, based on the Ni-ion.
Freshwater:
High quality NOEC/L(E)C10 values for chronic toxicity to freshwater fish are based on three fish species, Pimephales promelas,Oncorhynchus mykiss, and Brachydanio rerio. The NOEC/L(E)C10 values for fish range from 40 μg/L for Brachydanio rerio(Dave & Xiu, 1991) to 1,548 μg/L for the Oncorhynchus mykiss (Deleebeeck et al., 2005a).
The following table indicates those NOEC or EC10 values that have been carried forward for the HC5-& PNEC derivation
Key Study (freshwater Fish) |
Selected values for the most sensitive endpoints used for derivation of the freshwater HC5 |
||
Species |
Endpoint |
Value (µg/L) |
|
Birge et al., 1984 |
Pimephales promelas |
NOEC |
57 |
Nebeker et al., 1985 |
Oncorhynchus mykiss |
NOEC |
134 |
Dave & Xiu., 1991 |
Brachydanio rerio |
NOEC |
40 |
Marine:
Chronic toxicity values are reported for two marine fish species. EC10 values range from 3599 μg Ni/L for growth of the topsmelt, Atherinops affinis (Hunt et al., 2002), to 20760 μg Ni/L for growth of the sheepshead minnow, Cyprinodon variegatus(Golder et al., 2007).
Key Study (marine Fish) |
Selected values for the most sensitive endpoints used for derivation of the marine HC5 |
||
Species |
Endpoint |
Value (µg/L) |
|
Golder, 2005 |
Cyprinodon variegatus |
EC10 |
20,760 |
Hunt et al., 2002 |
Atherinops affinis |
EC10 |
3,599 |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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