Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-686-1 | CAS number: 109-60-4
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Report on human maximization studies. Report to RIFM
- Author:
- Kligman AM
- Year:
- 1 978
- Bibliographic source:
- cited in rifm.org for CAS No. 109-60-4
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A maximization test was carried out with test material in petrolatum on 9 males and 16 female, healthy, volunteers. Application was under occlusion to the same site on the forearms of all subjects for five alternate day 48 hour periods. Patch sites were pretreated for 24 hours with 2.5% sodium lauryl sulfate under occlusion. Following a ten day rest period, a challenge patch was applied to a different site on the opposite upper arm for 48 hours under occlusion. The challenge site was pre-treated for one hour with a 10% aqueous solution of sodium lauryl sulfate. The challenge site was read on removal of the patch and 24 hours thereafter.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propyl acetate
- EC Number:
- 203-686-1
- EC Name:
- Propyl acetate
- Cas Number:
- 109-60-4
- Molecular formula:
- C5H10O2
- IUPAC Name:
- propyl acetate
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- 9 male and 16 female, healthy, volunteers
- Route of administration:
- dermal
- Details on study design:
- 48 hour closed patch test, vehicle was petrolatum
Results and discussion
- Results of examinations:
- In a concentration of 2 %, propyl acetate caused no local effects and is thus not a skin sensitizer in this test.
Applicant's summary and conclusion
- Conclusions:
- not sensitising
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
