Registration Dossier
Registration Dossier
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EC number: 246-278-9 | CAS number: 24468-13-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis product 2-ethylhexanol: acutely harmful to aquatic algae.
Hydrolysis product HCl: acutely very toxic to aquatic algae (pH dependent).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 16.6 mg/L
- EC10 or NOEC for freshwater algae:
- 5.3 mg/L
Additional information
2-ethylhexyl chloroformate is expected to hydrolyse rapidly in contact with water (DT50 at 25 °C and pH 7 = 30.2 min, Safepharm, 2003) to form 2-ethylhexanol (CAS 104-76-7), hydrogen chloride (HCl, CAS 7647-01-0) and CO2. No data are available regarding the toxic effect of the parent compound to aquatic algae and cyanobacteria. Toxicity of the hydrolysis product 2 -ethylhexanol was assessed in a study with Desmodesmus subspicatus according to EU method C3. The ErC50 is reported to be 16.6 mg/L (Huels AG 1991).
The hydrolysis product HCl showed acutely very toxic effects due to the low pH in a study with Raphidocelis subcapitata according to OECD guideline 201. The 72h EC50 is reported to be 0.492 mg/L (OECD SIDS, 2002).
Species | Results | Remarks | Reference |
Desmodesmus subspicatus (formerly: Scenedesmus subspicatus | ErC50 (72 h) = 16.6 mg/L ErC10 (72 h) = 5.3 mg/L EU method C3 | Hydrolysis product 2-ethylhexanol; reliability: 2; key study | Huels AG, 1991 |
Raphidocelis subcapitata (formerly: Selenastrum capricornutum and Pseudokirchneriella subcapitata) | EC50 (72 h) = 0.492 mg/L (acid equivalent to pH 5.3), NOEC (72 h) = 0.097 mg/L (acid equivalent to pH 6.0), OECD TG 201 | Hydrolysis product HCl; reliability: 2; key study | OECD, 2002 |
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